Ending a struggle is a recognition of defeat when nothing is gained by it. The end of struggle should be based on getting the maximum without losing face. It should be the result of getting what one was fighting for and not selling a cause cheaply. If the causes of a struggle like repression and domination aren’t dealt with, its seed will continue to grow.
As for the Dalai Lama to say he has lost lost for Tibet, he must feel frustrated by his long struggle to make China bow to his demands. If there is real democracy in China it doesn’t matter if Tibet is an independent country or an autonomous region of China. However as china has been successful in implanting one country,two systems with Hong Kong, the same should apply to Tibet. However it remains unlikely that the Chinese government will follow this step as other regions in China will ask for the same political rights.
It will also remains to see if China will end its struggle to have Taiwan back by recognizing its independence. That will also be a turning point in its policy towards this territory and the other neighbouring countries , like Burma, whose repressive systems it supports.